The upside was that two of the Minnesota's three runs against Toronto ace Roy Halladay were driven in by designated hitter Rondell White, who batted cleanup, and third baseman Tony Batista, who batted seventh.
White, who was hitless in three at-bats, drove in the game's first run with a sacrifice fly in the first inning. Batista, who went 1-for-3, hit a seventh-inning home run.
And even hitless second baseman Luis Castillo, batting second, had a sacrifice bunt in that first inning to help put the first run into scoring position.
But the downside was the three combined to go just 1-for-9 with three strikeouts -- albeit, much of the struggles coming against Halladay.
"We're not going to judge (off one game) today," center fielder Torii Hunter said, "because Roy Halladay had a holiday."
REPLAY: The middle of the Twins batting order -- Nos. 3 through 6 -- went a combined 0-for-15 with four strikeouts in a 6-3 loss to Toronto in the season opener, offering little suggestion that much has changed since the meat in the lineup looked more like bone last year.
The Twins, who scored an American League-low 688 runs last year, took an early 1-0 lead but couldn't add on until they trailed 4-1, eventually getting a pair of solo homers from ex-Blue Jays Tony Batista and Shannon Stewart to close to within one. But the Jays put the game away on right fielder Alex Rios' two-run homer in the eighth.
Meanwhile, in a battle of past AL Cy Young Award winners -- Roy Halladay (2003) and Johan Santana (2004) -- the trends held. Halladay improved to 5-0 lifetime against the Twins with 7 2/3 strong innings, and Santana fell to 2-3 against Toronto after failing to get out of the sixth.
Santana is 1-2 with a 6.50 REA against Toronto since the start of last season. After a 10-3 loss against them last year, several Blue Jays said Santana was tipping his pitches. He didn't seem to have that problem against other teams, and he came back to beat the Blue Jays with seven strong innings less than two weeks later. But judging from Tuesday's results, they seem to have his number.